Human nickel sulfate absorption

Table V. Effect of Ascorbic Acid (1 g) on the Absorption of Nickel (5 mg) as Nickel Sulfate in Human Subjects...

Following inhalation exposure, about 20-35% of nickel deposited in the lungs of humans is absorbed into the bloodstream. Absorption from the respiratory tract is dependent on the solubility of the nickel compound, with higher urinary nickel observed in workers exposed to soluble nickel compounds (nickel chloride, nicke sulfate) than in those exposed to less-soluble nickel compounds (nickel oxide, nickel subsulfrde). Following oral exposure, about 27% of the nickel given to humans in drinking water was... 

Compared to normal subjeets, niekel absorption did not differ in niekel-sensitive individuals. In a study using excised human skin, only 0.23% of an applied dose of niekel ehloride permeated skin after 144 hours when the skin was not oeeluded, while 3.5% permeated oeeluded skin (Fullerton et al. 1986). Nickel(II) ions from a ehloride solution passed through the skin 50 times faster than nickel(II) ions from a sulfate solution (Fullerton et al. 1986). Applieation of niekel ehloride in a sodium lauiyl sulfate solution (0.25%, 2%, or 10%) to exeised human skin resulted in a dose-related increase in the penetration of niekel during a 48-hour period (Frankild et al. 1995). 

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