Human liver homogenates, capacity

As a prodrug, enalapril is essentially inactive as an ACE inhibitor. Thus, it must be enzymatically converted to enalaprilat, and liver homogenates of rats, dogs, rhesus monkeys, and humans have that capacity (128). In humans and in all nonhuman species except the rhesus monkey, deesterification is the only metabolism which is observed. In monkeys, a small amount of the desproline metabolite of enalaprilat has been detected (128). Absorption of enalapril is reported to be 39% in rats, 64% in dogs, and 60-70% in humans (128). 

Fig. S. Distribution, of acid phosphatase and giucose-6-phosphataae activity in sub-fractions of homogenate frctn human liver shown in relation to the capacity of Uie subfractions for stimulating m.ierosoraal synthesis of tauro- and glyeocholie acids. C— , Synthesis-increasing capacity, m/jmoles conjugates/mg protein from the respective fractions added to basal quantity of microsome protein. ---- , Acid phosphatase activity. Glucose-S hosphataae activity. N, nuclear fraction ...

---