Human liver conjugates, capacity

Fig. S. Distribution, of acid phosphatase and giucose-6-phosphataae activity in sub-fractions of homogenate frctn human liver shown in relation to the capacity of Uie subfractions for stimulating m.ierosoraal synthesis of tauro- and glyeocholie acids. C— , Synthesis-increasing capacity, m/jmoles conjugates/mg protein from the respective fractions added to basal quantity of microsome protein. ---- , Acid phosphatase activity. Glucose-S hosphataae activity. N, nuclear fraction ...

The mechanism,s behind the changes in the synthesis of taurocholic and glycocholic acids in human liver in patients with obstructive jaundice ivas analyzed by Schersten (1967a,b). The following possible explanations for a lower capacity of the synthesis of bile acid conjugates or for an altered conjugation pattern in such cases were provioundcd. 

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