Human apical sodium-dependent bile

Balakrishnan, A., Sussman, D.J. and Polli, J.E. (2005) Development of stably transfected monolayer overexpressing the human apical sodium-dependent bile acid transporter (hASBT). Pharmaceutical Research, 22, 1269-1280. 

Jung, D., Fried, M., and Kullak-Ublick, G. A. (2002) Human apical sodium-dependent bile salt transporter gene (SLC10 A2) is regulated by the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 277, 30559-30566. 

The apical localized sodium-dependent bile add transporter (ASBT) is expressed in the human duodenum and ileum and is barely detectable in colon [16]. ASBT transports bile adds such as glycodeoxycholate and chenodeoxycholic add (XX) [49, 50]. Few examples exist where the bile acid scaffold has been used as a promoiety for a prodrug approach. ASBT has micromolar affinities for the natural substrates, and the studies on ASBT are too few to make a general statement on the potential and role of this transporter in drug absorption [49, 50]. 

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