Human acid glucosylceramidase activity-based probe

Development of a Human Acid Glucosylceramidase Activity-Based Probe 

Human acid glucosylceramidase, or GBA (glucosidase, beta, acid), catalyzes the hydrolysis of glucosylceramide to glucose and ceramide. As such, it is responsible for the penultimate step in the turnover of glycosphingolipids, an important metabolic pathway malfunctioning of which is responsible for 

Fiaure 13-4 two-step bioorthog- situ probe, (c) Tuning of the leaving group 

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See also in sourсe #XX -- [ , ]

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