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HT4 agonism

The very weak agonist properties of 2-methyl-5HT (4) suggested an unfavorable Ai,3 strain interaction between the 2-methyl group and the ethylamine side chain in the conformation(s) required for 5-HT4 agonism. Such Ai 3 strain would predominate in conformers wherein Tau 1 = 180°. Figure 1 illustrates this set of conformers, wherein the side chain amino group may be positioned at rotamer sites A, B, and C [13]. [Pg.100]

See other pages where HT4 agonism is mentioned: [Pg.99]    [Pg.100]    [Pg.100]    [Pg.102]    [Pg.103]    [Pg.105]    [Pg.105]    [Pg.106]    [Pg.106]    [Pg.112]    [Pg.112]    [Pg.113]    [Pg.118]    [Pg.99]    [Pg.100]    [Pg.100]    [Pg.102]    [Pg.103]    [Pg.105]    [Pg.105]    [Pg.106]    [Pg.106]    [Pg.112]    [Pg.112]    [Pg.113]    [Pg.118]    [Pg.236]    [Pg.196]    [Pg.200]    [Pg.330]    [Pg.342]    [Pg.437]    [Pg.52]   
See also in sourсe #XX -- [ Pg.11 , Pg.99 , Pg.100 , Pg.102 , Pg.103 , Pg.108 , Pg.111 , Pg.111 , Pg.112 , Pg.112 , Pg.118 ]



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