How Enzymes Work

Garcia-Viloca M, Gao J, Karplus M, Truhlar DG (2004) How enzymes work Analysis by modem rate theory and computer simulations. Science (Washington, DC) 303(5655) 186-195... 

Garcia-Viloca, M. Gao, J. Karplus, M. Truhlar, D.G., How enzymes work analysis by modern reaction rate theory and computer simulations, Science 2004, 303, 186-195. 

Concept "One of the great intellectual challenges presented to Science by Nature is a proper understanding of how enzymes work. At one level we can explain enzyme catalysis -what an enzyme does is bind, and thus stabilise, selectively the transition... 

Explain how enzymes work and describe the different types of enzymes. 

It would be distinctly arrogant to say that we understand how enzymes work. At best we catch glimpses of their action. One model involves the key-and-lock concept—an attempt to rationalize their specificity. A much simplified presentation is shown in Fig. 7.115. The idea is that certain shapes in the enzyme structure are precise fits for a part of the reactant molecule. A famous formulation of this is the Michaelis-Menten kinetics. If E is the enzyme and R is some part of a reactant (a complex biomolecule),... 

It is not the purpose of this essay to describe how enzymes work. Many excellent texts cover the subject. Enzymes are components of the system by which living cells, plants, and animals produce energy and nutrients. Possible food sources in the... 

Chapter 8, How Enzymes Work, starts with a description of the basic chemical mechanisms that are exploited by enzymes. The latter half of this chapter presents a detailed description of how three enzymes—chymotrypsin, RNase, and triose phosphate isomerase—exploit these basic mechanisms of enzyme catalysis. 

Describe how enzymes work and how the structure and function of an enzyme is affected by changes in temperature and pH. 

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