How does nucleic acid chemistry affect the landscape

How does nucleic acid chemistry affect the landscape  

DNA can be construed as a modification of RNA, and the results of similar selections that start from either a DNA or an RNA pool are informative. Aptamers against reverse transcriptase selected from RNA pools [49] have different sequences and structures compared to those selected from DNA pools [50] the same is true for aptamers against ATP [13,51], The DNA aptamer against thrombin forms a G-quartet [12], whereas the RNA aptamer is predicted to form a stem-loop structure [52], 

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