Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Hot-melt extrusion

Within the pharmaceutical industry, granulation is a widely used process to prepare drug substance and excipient particles for compression. There are wet and dry granulation procedures herein high shear wet grannlation, fluid bed granulation and roller compaction will be discussed. [Pg.446]


HME hot melt extrusion ETCO long-term cost of ownership... [Pg.582]

Chokshi, R. J., H. K. Sandhu, R. M. Iyer, N. H. Shah, A. W. Malick, and H. Zia. 2005. Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion process as a means to manufacture solid dispersion/soJUflbarm ScB4 2463-2474. [Pg.525]

In-process controls such as stratined sampling, process analytical technology (PAT) application, and blend homogeneity. Assess modincation of dissolution through optimization of API characteristics and then perform assessment of specialized technologies [hot-melt extrusion (HME), spray-dried dispersion, solid dispersion, etc.] for long-term resolution... [Pg.645]

Fernando A. Alvearex-Nunez and Mark R. Leonard. Formulation of a poorly soluble drug using hot melt extrusion. The amorphous state as an alternaftwe. Pharm. Rey.7(4), July/August (2004),... [Pg.661]

Implants can be prefabricated and administered with the help of specialized injection devices such as trocars, often under local anesthesia. These implants can be manufactured by standard hot-melt extrusion,... [Pg.297]

FIGURE 6 Schematic of manufacturing process of reservoir design ring by hot-melt extrusion. [Pg.830]

Young, C. R., Dietzsch, C., and McGinity, J. W. (2005), Compression of controlled-release pellets produced by a hot-melt extrusion and spheronization process, Pharm. Dev. Technol., 10,133-139. [Pg.1216]

De Brabander, C., Vervaet, C., and Remon, J. P. (2003), Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion, J. Controlled Release, 89, 235-247. [Pg.1220]

Pressure extrusion Hot melt extrusion Use of supercritical fluids Inclusion complexation... [Pg.583]

Poly Ethylene Oxide) (PEO) Polymers. In the same family as PEG, but having higher molecular weights are POLYOX resins, which are water-soluble polymers. Because of their low melting point and unique swelling properties, coupled with the controlled rate of dissolution, POLYOX resins have been used to make sustained-release formulations by hot-melt extrusion.f ... [Pg.765]

Zhang, Feng McGinity, J.W. Properties of sustained-release tablets prepared by hot-melt extrusion. Pharm. Dev. Technol. 1999, 4 (2), 241-250. [Pg.772]

Aitken-Nichol, C. Zhang, Feng McGinity, J.W. Hot melt extrusion of acryhc films. Pharm. Res. 1996,13 (5), 804—808. [Pg.773]

Hot-melt extrusion is one of the most widely applied processing techniques in the plastics industry. Joseph Brama invented the extrusion process for the manufacturing of lead pipes at the end of the eighteenth century. However, hot-melt extrusion was not applied in the plastics industry until the mid-nineteenth century, when it was first introduced into a wire insulation polymer coating process. Today, hot-melt extrusion is not only widely applied in the production of polymeric articles but also in polymer production and compounding. Currently, more than half of all plastic products, including plastic bags, sheets, and pipes, are manufactured by this process. ... [Pg.2004]

The design of the extrusion screw has a significant influence on the efficiency of the hot-melt extrusion process. The function of the screw is to transfer the material inside the barrel and then to mix, to compress, and to melt the polymeric materials and to pump the molten mass through the die. Several parameters are used to define the geometrical features of the screw (Fig. 2). [Pg.2005]


See other pages where Hot-melt extrusion is mentioned: [Pg.484]    [Pg.440]    [Pg.445]    [Pg.445]    [Pg.499]    [Pg.508]    [Pg.509]    [Pg.509]    [Pg.524]    [Pg.620]    [Pg.620]    [Pg.637]    [Pg.655]    [Pg.254]    [Pg.226]    [Pg.829]    [Pg.864]    [Pg.1201]    [Pg.1216]    [Pg.619]    [Pg.767]    [Pg.767]    [Pg.768]    [Pg.1107]    [Pg.1112]    [Pg.1113]    [Pg.2004]    [Pg.2004]    [Pg.2004]    [Pg.2004]    [Pg.2004]    [Pg.2004]   
See also in sourсe #XX -- [ Pg.440 , Pg.445 ]

See also in sourсe #XX -- [ Pg.499 , Pg.508 , Pg.637 , Pg.645 , Pg.655 ]




SEARCH



Hot extrusion

Hot-melt extrusion process

Hot-melt extrusion technique

Melt extrusion

Polymers as Formulation Excipients for Hot-Melt Extrusion Processing of Pharmaceuticals

© 2024 chempedia.info