Host range, alternate serotypes, and capsid modifications

Host range, alternate serotypes, and capsid modifications 

Two strategies have been pursued to overcome this limitation and effectively broaden the cellular host range of rAAV vectors. The first is to utilize other rAAV serotypes, which may target other cellular receptors. Recent studies have shown an increased efficiency of gene delivery in lung, pancreatic islets, and glial cells with rAAV serotype 5 and an increase in the efficiency of delivery to muscle using rAAV serotype 1. The other approach has been to 

ADENO-ASSOCIATED VIRAL VECTORS FOR GENE THERAPY 

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