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Host-protective antigen resistance

Four different vaccines for Hib are licensed in the United States. All these vaccines are composed of Hib capsular polysaccharide conjugated to a protein carrier. All four vaccines use a different carrier. Polyribosyl ribitol phosphate (PRP) capsule is an important virulence factor that renders Hib resistant to phagocytosis by neutrophils in the absence of specific anti-capsular antibody. Antibody directed against PRP capsule of Hib is primarily responsible for host resistance to infection. The Hib vaccine is composed of the purified, capsular polysaccharide of Hib. Antibodies to this antigen correlate with protection against invasive disease. [Pg.209]

See other pages where Host-protective antigen resistance is mentioned: [Pg.341]    [Pg.352]    [Pg.359]    [Pg.434]    [Pg.255]    [Pg.256]    [Pg.201]    [Pg.173]    [Pg.178]    [Pg.200]    [Pg.538]    [Pg.236]    [Pg.231]    [Pg.446]    [Pg.492]    [Pg.51]   
See also in sourсe #XX -- [ Pg.48 , Pg.260 ]



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