Horner-Emmons Reagents on Supports

The loading of the resin 135 was calculated to be of the order of 3.4 mmol [69]. However, the stability of the reagent proved to be limited, and it had to be prepared immediately before use. Using 2 equiv. of the phosphonate resin, alkenes 136 were prepared from the corresponding carbonyl compounds 137 in good yields within 1 h at room temperature simply by stirring the mixture in THE. 

Alternatively, a solution of tlie carbonyl compound can be percolated through a column packed with the supported phosphonate [113], This, together with the possibility of recycling the resin by washing and reloading steps, enables continuous-flow processes. 

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