Honeycutt

An off-lattice minimalist model that has been extensively studied is the 46-mer (3-barrel model, which has a native state characterized by a four-stranded (3-barrel. The first to introduce this model were Honeycutt and Thirumalai [38], who used a three-letter code to describe the residues. In this model monomers are labeled hydrophobic (H), hydrophilic (P), or neutral (N) and the sequence that was studied is (H)9(N)3(PH)4(N)3(H)9(N)3(PH)5P. That is, two strands are hydrophobic (residues 1-9 and 24-32) and the other two strands contain alternating H and P beads (residues 12-20 and 36-46). The four strands are connected by neutral three-residue bends. Figure 3 depicts the global minimum confonnation of the 46-mer (3-barrel model. This (3-barrel model was studied by several researchers [38-41], and additional off-lattice minimalist models of a-helical [42] and (3-sheet proteins [43] were also investigated. 

J. D. Honeycutt, D. Thirumalai. Influence of optimal cavity shapes on the size of polymer molecules in random media. J Chem Phys 92 6851-6858, 1990. 

C.P. Weisskopf and J.N. Seiber, New approaches to the analysis of organophosphate metabolites in the urine of field workers, in ACS Symposium Series Biological Monitoring for Pesticide Exposure Measurement, Estimation, and Risk Reduction, eds. R.G.M. Wang, C.A. Franklin, R.C. Honeycutt, and J.C. Reinert, American Chemical Society, Washington, DC, pp. 206-214 (1989). 

W.J. Popendorf, Advances in the unified field model for reentry hazards, in Dermal Exposure Related to Pesticide Use Discussion of Risk Assessment, ed. R.C. Honeycutt, G. Zweig, and N.N. Ragsdale, ACS Symposium Series 273, American Chemical Society, Washington, DC, pp. 323-340 (1985). 

R.C. Honeycutt and E.W Day, Jr. (eds), Worker Exposure to Agrochemicals - Methods for Monitoring and Assessment, Lewis Publishers, Boca Raton, FL (2000). 

Honeycutt, R.C. and DeGeare, M.A., Worker Reentry Exposure to Chlorpyrifos in Citrus Treated with Lorsban 4E Insecticide, unpublished report, HERAC, Inc., December 10,1993. 

The results from the several studies that have been conducted to measure exposures associated with the use of chlorpyrifos are summarized in Tables 1 and 2. Table 1 summarizes results from mixer-loader and applicator studies reported by Honeycutt et al.1 Listed for each work description are the number of replicates, the arithmetic mean, and the geometric mean for the replicates from both the passive dosimetry measurements and the biomonitoring tech-... 

Honeycutt, R.C., Day, Jr., E.W., Shurdut, B.A., and Vaccaro, J.R., Use of simultaneous biological monitoring and dermal dosimetry techniques to determine the exposure of chlorpyrifos to applicators and re-entry workers, in Worker Exposure to Agrochemicals Methods for Monitoring and Assessment, Honeycutt, R.C. and Day, E.W., Jr., Eds., Lewis Publishers, Boca Raton, FL, 2000, chap. 2. 

Franklin, C. (1985) Occupational exposure to pesticides and its role in risk assessment procedures used in Canada, in Dermal Exposure Related to Pesticide Use, Honeycutt, R., Zweig, G., and Ragsdale, N.N., Eds., ACS Symposium Series No. 273, American Chemical Society, Washington, D.C. 

Worker exposure to agrochemicals methods for monitoring and assessment / R.C. Honeycutt, Edgar W. Day, Jr., editors p. cm. 

Richard C. Honeycutt, Ph.D., was born in Newport News, VA, in 1945. He attended Anderson University in Anderson, IN, from 1963 to 1967 and earned an A.B. in Chemistry. He received his Ph.D. in Biochemistry from Purdue University in 1971 and served as a Postdoctoral Fellow from 1971 to 1973 at the Smithsonian Institution s Radiation Biology Laboratory. Dr. Honeycutt worked as a Senior Chemist at Rohm and Haas Company from 1973 to 1976 and as a Senior Metabolism Chemist at Ciba Geigy from 1976 to 1989. Currently, he is President of the Hazard Evaluation and Regulatory Affairs Company, Inc., which he founded in 1990, and is an analytical biochemist and field research specialist/consultant engaged in exposure assessment of pesticides to humans and the environment. 

Dr. Honeycutt is a former chair and council representative for the Central North Carolina Section of the American Chemical Society. He is also a former chair of the Division of Agrochemicals for the American Chemical Society and is currently the Nominations Committee Chair for the Division of Agrochemicals. He served on the ACS Committee on Environmental Improvement for 9 years and is a consultant for this ACS committee. He is also a member of the International Commission of Occupational Health. 

An application of transport and compartment-type models to hazard analysis is described in the paper by Honeycutt and Ballantine (19). The compound CGA-72662 running off from agricultural areas into surface waters was modeled in order to set safe application procedures consistent with the protection of aquatic environments. Patterson, et al (2 0) have adapted the UTM model to a software package that is generally applicable to fate assessments of toxic substances in air, water, soil and biota. Their work, now in working draft form, is being used by Dr. William Wood and Dr. Joan Lefler in the Office of Toxic Substances of the U.S. Environmental Protection Agency. 

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