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Homologation rearrangement during

Homologation of a broad range of aliphatic acid structures and carbon numbers, with extensive rearrangement during the homologation of certain branched-chain acids. [Pg.234]

The suitably protected amino acid is activated as the mixed anhydride and treated with diazomethane to produce the corresponding diazo ketone. Rearrangement in the presence of water furnishes the p-amino acid. Diazomethane contains varying amounts of water, which is able to hydrolyze the activated amino acid. This leads to subsequent methylation by diazomethane to form the methyl ester as a side product. This cannot easily be removed from the diazo ketone, but can be separated during work-up of the homologated amino acids. [Pg.228]

See other pages where Homologation rearrangement during is mentioned: [Pg.409]    [Pg.1569]    [Pg.1505]    [Pg.422]    [Pg.656]    [Pg.232]    [Pg.635]    [Pg.499]    [Pg.877]    [Pg.41]    [Pg.222]    [Pg.877]    [Pg.237]    [Pg.233]    [Pg.43]    [Pg.235]    [Pg.105]    [Pg.1293]    [Pg.109]    [Pg.205]    [Pg.843]    [Pg.843]    [Pg.148]    [Pg.35]    [Pg.297]    [Pg.1162]    [Pg.119]    [Pg.500]    [Pg.49]    [Pg.384]    [Pg.146]    [Pg.1000]    [Pg.115]    [Pg.378]    [Pg.1484]    [Pg.1683]    [Pg.415]    [Pg.843]    [Pg.259]    [Pg.594]    [Pg.409]    [Pg.334]    [Pg.189]    [Pg.24]    [Pg.2417]    [Pg.374]   
See also in sourсe #XX -- [ Pg.235 ]



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