Homochiral supramolecular architecture

By means of various analytical techniques, we can observe homochiral supramolecular architectures in a wide range of phases, from the crystalline state to a dilute solution, as described above. If we want to apply these systems for practical use. such as in optical resolution of racemates, the next crucial subject is how to manipulate the homochiral assemblies. In the case of separation of conglomerates, one can often sort the enantiomers by hand, as was performed by Pasteur. Although this method can be applied only when crystals have sufficient size to allow determination of their sign of rotation, an alternative technique named "preferential crystallization" was developed, which has its origin in 1866 in the work of Gernez. " He observed that a supersaturated solution of racemic dextrorotatory salt yielded only... 

Compound 72 was shown to display enantioselectivity in the extraction of chiral potassium salts from water into the organic phase.105 The supramolec-ular polymer possesses a homochiral helical architecture onto which one of the anionic enantiomers preferentially binds. Intriguingly, for some of the anions the octamer and polymer showed opposite selectivity, illustrating the difference in supramolecular chirality of the two systems. Furthermore, the polymer was capable of inducing a Cotton effect in the achiral compound potassium A-(2,4-dinitrophenyl)glycinate. Since the apolar side chains would... 

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