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Hofmann elimination reaction regiochemistry

If it is possible for the regiochemistry of the formation of the double bond to be in doubt, then in a syn-E2 reaction Hofmann elimination is nearly always followed. This is in contrast to the situation of the anti-E2 reaction in which either the Zaitsev or the Hofmann elimination could occur, depending on the circumstances. [Pg.282]

An example of a reaction that shows this latter regiochemistry is the Hofmann exhaustive methylation, which is sometimes called, rather ambiguously, the Hofmann degradation (this is a term best avoided, because it is sometimes also used to describe the Hofmann rearrangement). In this reaction, an amine is methylated with methyl iodide until the quaternary ammonium iodide is formed. This is then treated with moist silver oxide to convert the iodide to the hydroxide. Write out the final elimination step that occurs on heating. [Pg.277]


See other pages where Hofmann elimination reaction regiochemistry is mentioned: [Pg.547]    [Pg.326]    [Pg.328]    [Pg.328]    [Pg.938]    [Pg.1000]    [Pg.996]    [Pg.938]    [Pg.1000]    [Pg.311]    [Pg.766]    [Pg.966]    [Pg.277]   
See also in sourсe #XX -- [ Pg.937 ]

See also in sourсe #XX -- [ Pg.937 ]

See also in sourсe #XX -- [ Pg.765 ]

See also in sourсe #XX -- [ Pg.964 ]




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