HIV-RT inhibitor

Initially, we removed one and then two rings from the catechins, and then reduced as much as possible the number of oxidation-activating reactive phenolic groups. The nature of the molecular simplifications undertaken is illustrated in Figure 8.9. At the present stage of development, these compounds are only 10 to 100 times less active than the catechins on which they are based. However, we also discovered these agents to represent a fundamentally new class of inhibitors they illustrated a nearly uncompetitive pattern of inhibition. This was a surprise, as there are no other such HIV-RT inhibitors described. Indeed, we already suspected that we had discovered a new class of inhibitors, because the activity... 

Figure 2.149. (Liaison). Given a protein structure and series of ligands with known activities, Liaison uses the Linear Interaction (LIA) method to generate a model for predicting binding energies. In the example shown here, Liaison predicts the activities of 20 HIV-RT inhibitors with an accuracy of about 1 kcal/mol...

Table 1. In vitro activity of HIV-RT inhibitors. Values refer to the active enantiomers whose absolute configurations were determined by X-ray crystallography, except for 2 which is achiral.

Figure 5.9 The HIV RT inhibitor Retrovir (zidovudine, AZT) and the HIV protease inhibitor Invirase...

Metab. of the marine mollusc Buccinulum corneum. HIV reverse transcriptase (HIV-rt) inhibitor. Exhibits antibacterial props. 

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