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Towards a Pharmacophore Model for the nd-AR Subtype 12.2.2.1 A Preliminary Model 

These considerations suggested that our model incorporates the most relevant structural features of the inhibitors of the ald adrenoceptor subtype. 

To test this hypothesis, we investigated a new series of phenylpiperazines, bearing a pyrimido[5,4-d]indolo group as the terminal heterocyclic moiety like compound 5, showing preferential affinity for the ald-AR subtype. A selection of 16 compounds, with affinity values spanning over 3.5 orders of magnitude, was used to generate a set of 10 five-feature pharmacophore hypotheses [18] that we compared with the previously described five-feature pharmacophoric 

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