Histone lysine methyltransferases HKMTs

We turn now to histone lysine methyltransferase (HKMT) which catalyzes the methylation of the N-terminal histone tail of chromatin using the 5-adenosyl-methionine (SAM) cofactor as the methylating agent (see Fig. 1). 

Histone lysine (K) methyltransferase (HKMTs) may lead to mono, di- and trimethy-lation of the E-amino group and the extent of modification at a specific site controls the recruitment of the effector proteins. Two unequally populated folds are presently known the SET domain-containing family and the Dotl family (for a recent review, see Ref. [70])... 

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