Histamine early reviews

G-protein coupled receptor family comprises most well-known cell surface receptors including the major drug targets, as previously stated. Early PAL results have been reviewed in several papers, and book chapters. For opiate, NMDA, sigma, benzodiazepine, GABA, acetyl choline, and adrenerg, serotonine receptors see [52,59,60], and for purinerg, histamine, and dopamine receptors see [61]. 

This concept has been repeatedly advanced by Leriche and his school (F7, L6, L7, M46-M47) ever since Kaufman introduced it in 1908 (KIO). It found some support in the early work of Anderson, Farmer and Fogel-son, who reported decreased mucin content in patients with peptic ulcer (A3-A5). However, with application of more exact iodometric methods (G6, G7) for the quantitation of mucin in the gastric juice, neither the reviewer (G6, G7) nor others who worked with this technique abroad (K6, K20, M52) and in this country (T33) could demonstate mucin deficiency in patients with peptic ulcer. This was true for gastric juice collected both under fasting conditions and after alcohol or histamine stimulation. Similar negative findings were recorded by authors who worked with other methods (B35, 13). 

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