Histamine antagonists molecular modeling

De Esch IJP, Mills JEJ, Perkins TDJ, Romeo G, Hoffmann M, Wieland K, Leurs R, Menge WMPB, Nederkoorn PHJ, Dean PM, Timmerman H. Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE. J Med Chem 2001 44 1666-1674. 

Molecular orbital calculations on models have provided the intergroup distances which may explain how cortisol functions as an antagonist in the Inflammatory response to histamine and serotonin. The distance between the 3-0X0 and lip-hydroxyl group, e.g., approximates the internitrogen distance previously calculated for serotonin. 

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