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Higher-throughput surrogate assays

Higher-Throughput Surrogate Assays for Quantifying the Potential for Bioactivatirai 528... [Pg.511]

The octanol/water partition coefficient (log Poet) is used as a surrogate of the passive transcellular permeation. Ho vever, it has two drawbacks (i) low to moderate correlation with in vivo absorption (ii) time-consuming assay. Therefore, various artificial membrane assays were extensively investigated as alternative approaches with better predictive power and allowing for higher throughput. [Pg.125]

See other pages where Higher-throughput surrogate assays is mentioned: [Pg.531]    [Pg.30]    [Pg.394]    [Pg.212]    [Pg.382]    [Pg.846]   


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Surrogate assays

Surrogates

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