High shear homogenization techniques

Liquid shearing, such as high pressure homogenization, solid shear, such as bead milling and the extrusion of frozen cells are the most common mechanical methods for cell disruption (D souza and Killedar, 2008 Hatti-Kaul and Mattiasson, 2003). These methods are mainly based on the use of mechanical force to disrupt the cell. Some of these techniques, such as bead milling, have already found applications on a large scale (Prasad, 2010). 

The introduction of the expander, a high-shear extruder with cut-flight screw, revolutionized oilseed extraction practices in the latter half of the 1980s. By 1990, over 80 percent of the soybean and cottonseed tonnage processed domestically used this technique. The expander heats, homogenizes, and shapes... 

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