High potency dosage

In the human market, oral and parenteral dosage forms are prepared from the crystal. However, because of the extremely high potency, more dilute (0.1—10%) forms are avabable. These include dilutions with mannitol, triturations on dicalcium phosphate or resins, and spray-dried forms. Prices for these forms are driven by that of the crystal, which in early 1996 was ca 9.50/gram (95). Prices for the vitamin have risen during the first half of the 1990s. However, Htde growth in price beyond inflation is anticipated. 

Buccal Rapid onset of action No first-pass metabolism Dosage form recoverable Convenient Taste Only suitable for low dose (high potency) drugs Tablets, mouthwashes... 

Alfacalcidol and calcitriol have some advantages over calciferol, but their high potency involves a risk of hypercalcemia even after small dosage increments, because of increased intestinal calcium absorption. Because of this, constant vigilance is required to prevent hypercalcemia, especially in patients with chronic renal insufficiency and associated renal osteodystrophy. 

These three mescaline analogs (table I) have been assayed in normal subjects by procedures previously outlined (Shulgin et al. 1969). Both of the alkoxy homologs are effective as psychotomimetics at dosages of 60 mg. orally, with clear threshold effects being noted in some subjects at levels as low as 10 mg. These bases differ from mescaline in that the onset of action occurs sooner (within the first hour) and there is no nausea noted, but otherwise the time course and much of the qualitative content of the intoxication are similar to those of mescaline. The sulfur compound thio-mescaline (3) is also of unexpectedly high potency and is an effective psychotomimetic in man at oral doses of 30 mg. The... 

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