High-flux dialyzer hemodialysis with

Environmental and iatrogenic exposure can result in aluminum overload in dialysis patients and evident osteomalacia, anemia and dementia [46]. Furthermore, acute intoxication with aluminum can lead to encephalopathy and death [47]. Hemoperfusion, hemodialysis, or hemofiltration combined with desferoxamine (DFO) can effectively remove aluminum [48]. Hemodialysis with a high flux dialyzer and hemofiltration are likely superior to charcoal hemoperfusion [48, 49]. In aluminum intoxicated dialysis patients, improvements in osteomalacia [50], anemia [51], and dementia [52] have been demonstrated with chelation. 

Fall in glomerular filtration rate in a rapid and dose related fashion if dose >1 g/m Charcoal hemoperfusion and sequential hemodialysis if severe renal toxicity (significant clearance of methotrexate can be achieved with high-flux dialyzers... 

Pressure Control of the Ultrafiltration Rate During Hemodialysis with High-Flux Dialyzers and the Time Dependence of Membrane Transport Parameters... 

The results of this investigation which are clinically significant are 1) an accurate and simple means for controlling ultrafiltration during hemodialysis with "high flux" dialyzers has been developed, and 2) a formula which can accurately predict the ultrafiltration rate from measurement of hydrostatic pressures alone has been determined. It is now possible for any hemodialysis clinic to benefit from the use of high flux dialyzers by implementing the pressure control of ultrafiltration as described here. 

Matzke GR, Frye RF, Nolin TD. Vancomycin removal by low- and high-flux hemodialysis with polymethylmethacrylate dialyzers. J Am Soc Nephrol 1999 10 193A. 

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