High density lipoproteins delipidation

High-density lipoproteins (HDL) and very low-density lipoproteins (VLDL) are synthesized in the liver. LDL is produced in the blood stream as VLDL particles are partially delipidated by lipoprotein lipase, a triglyceride hydrolysing enzyme located on the luminal surface of vessels in sites such adipose tissue. 

Scanu, A. M., and Edelstein, C., Solubility in aqueous ethanol of the small molecular weight peptides of very low-density and high-density lipoproteins relevance to the recovery problem during delipidation of serum lipoproteins. Anal. Biochem. 44, 576-588 (1971). 

The liver synthesizes VLDL particles which undergo the same form of delipi-dation as chylomicrons by the action of lipoprotein lipase. This results in the formation of an intermediate density lipoprotein (IDLl whieh becomes low density lipoprotein (LDL) when further delipidated. LDL may be removed from the circulation by the high affinity LDL receptor or by other scavenger routes which arc thought to be important at high LDL levels and the main way in which cholesterol is incorporated into alhen>maious plaques. 

---