High-altitude pulmonary edema

Maggiorini M, Brunner-la Rocca H, Peth S, Fischler M, Bohm T, Bernherm A et al. Both tadalafll and dexam-ethasone may reduce the incidence of high-altitude pulmonary edema. Ann Int Med 2006 145(7) 497-506. 

Adult respiratory distress syndrome Pulmonary hypertension-associated edema (cardiogenic) Congestive heart failure Mitral stenosis Hypoalbuminemia Veno-occlusive disease Lymphatic dysfunction Unknown mechanisms High-altitude pulmonary edema Neurogenic pulmonary edema Narcotic-induced pulmonary edema... 

As in the case of the CYPllBl gene, many CY-P11B2 variants have now been defined from chn-ical studies. For review, see [2071]. The many variants [2072, 2073] have been related to a number of diseases, including congenital hypoal-dosterism [2074], salt-wasting syndrome [2075], adenoma [2076, 2077], treatment for diabetic nephropathy [2078], high-altitude pulmonary edema [2079,2080], metabolic syndrome [2081], hypertension [2082-2095], stroke [2096], atrial fibrillation [2097], and other cardiovascular risks [2098]. 

High-Altitude Pulmonary Edema High-altitude pulmonary edema is the most common cause... 

Hultgren, R.N., High altitude pulmonary edema hemodynamic aspects, Int. J. Sports Med., 18, 20, 1997. 

Adaptation to CO toxicity also seems to occur in humans. Doing experiments on herself, KiUick (1940) found diminished symptoms and lower COHb on chronic exposure to CO than in the beginning, which is in accord with the data of Haldane and Priestley (1935). Adaptation to hypoxia is the reason why people living at high altitudes feel perfectly normal while a visitor Irom the plains may feel quite unwell. Indian and Pakistani soldiers are facing one another in Siachen of Kashmir, the highest place for any military confrontation in the world. Unless the soldiers are acch-matized before they go to Siachen, many develop fatal pulmonary edema if they are acclimatized, the incidence of pulmonary toxicity is considerably reduced. 

A disorder occurring in individuals exposed to high altitudes (about 3048 m [10,000 ft]) for relatively long periods (24 hours or more). It presents as malaise, headache, and vomiting attributed to cerebral and pulmonary edema. It is probably related to both hypoxia and decreased atmospheric pressure. It may be prevented by proper acclimatization. Acute Radiation Syndrome... 

Anoxemia may induce pulmonary edema. In fact, pulmonary edema occurs after prolonged exercise among people who live at high altitudes. It is also observed among those who return to high altitudes after a 1- or 2-week stay at sea level. In such cases, it has been suggested that pulmonary edema results from vasoconstriction of the venules distal to the capillaries. 

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