Hypoxanthine-guanine HGPRT

EphR erythropoietin-producing hepatocellular receptor HGPRT hypoxanthine-guanine phosphoribosyltransferase... 

DNA = Deoxyribonucleic acid HGPRT = hypoxanthine-guanine phosphoribosyl transferase RNA = Ribonucleic acid -= negative result + = positive result (+) = weakly positive result... 

Fig. 13.1 Pathways of thiopurine metabolism. The positions of two polymorphically expressed enzymes, TPMT (thiopurine methyl transferase) and ITPA (inosine triphosphate pyrophosphatase), are shown. HGPRT, hypoxanthine guanine phosphoribosyl transferase 6-TIDP, 6-thioi-nosine diphosphate 6-TIMP, 6-thioinosine monophosphate 6-TITP, 6-thio inosine trinophosphate...

HGPRT Hypoxanthine guanine phosphoribosyltransferase MES 2- (N-Morpholino) ethanesulfonic acid... 

Table 7.1.4 Concentration range of purine and pyrimidine metabolites in urine (pmol/mmol creatinine) from patients. ADA Adenosine deaminase, APRT adenine phosphoribosyltransferase, ASA adenylosuccinate lyase, DHP dihydropyrimidinase, DPD dihydropyrimidine dehydrogenase, HGPRT hypoxanthine-guanine phosphoribosyltransferase, PNP purine nucleoside phosphorylase, TP thymidine phosphorylase, UMPS uridine monophosphate synthase, / -UP fi-ureidopropionase... 

HGPRT Hypoxanthine-guanine phosphoribosyl transferase (also called HPRT) an enzyme involved in the utiliza-... 

Note PNP = Purine Nucleotide Phosphorylase HGPRT = Hypoxanthine-Guanine Phosphoribosyl Transferase... 

EMA epithelial membrane antigen HGPRT hypoxanthine-guanine phosphoribosyl... 

A11 diseases are autosomal recessive unless otherwise indicated. AD, autosomal dominant XLR, X-linked recessive PRPP, 5-phosphoribosyl-l-pyrophosphate HGPRT, hypoxanthine-guanine phosphoribosyl-transferase. 

HGPRT hypoxanthine guanine phosphoribosyl transferase NSAID nonsteroidal anti-inflammatory drug PRPP phosphoribosyl pyrophosphate (synthetase)... 

HGPRT Hypoxanthine-guanine phosphoribosyltransferase the enzyme that catalyzes the synthesis of inosine monophosphate (IMP) and guano-sine monophosphate (GMP) from hypoxanthine and guanine, respectively. It makes up part of the purine salvage pathway, a way of recycling purine bases back to the nucleotides. 

HGPRT hypoxanthine guanine phosphoribosyltransferase deficiency PNP purine nucleoside phosphorylase deficiency... 

Fig. 4. Metabolism of allopurinol and oxipurinol to ribonucleotides that act as inhibitors of orotidylic decarboxylase. OPRT = orotate phosphoribosyltransferase HGPRT = hypoxanthine-guanine phospho-ribosyltransferase.

Possession of a genetic marker, such as the lack of an enzyme, to allow cell selection. For example, myelomas deficient in HGPRT (hypoxanthine guanine phosphoribosyl transferase) are commonly used. This allows selection of hybridomas in HAT medium (see selectable gene markers ). 

TK) Thymidine kinase (HGPRT) hypoxanthine-guanine phosphoribosyl transferase. 

Fig. 5. Schematic diagram showing the proposed linkage between P5C and purine nucleotides in erythrocytes. Abbreviations are the following G-6-P, glucose 6-phosphate 6-PG, 6-phosphogluconate Ru-5-P, ribulose-5-phosphate R-5-P, ribose 5-phosphate PP-ribose-P, phosphoribosyl pyrophosphate A, adenine G, guanine Hx, hypoxanthine AMP, adenosine monophosphate GMP, guanosine monophosphate IMP, inosine monophosphate PRT, adenine phosphoribosyltransferase HGPRT, hypoxanthine, guanine phos-phoribosyltransferase.

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