2- HEXYNOIC ACID, methyl ester

HEXYNOIC ACID, methyl ester, 55, 73 2-Hexynoic acid, 5-methyl-, methyl ester,... 

Alternatively, the hydrozirconation of 4 can be performed with i-BuZrCp2Cl generated in situ by the treatment of Cp2ZrCl2 with i-BuMgCl in benzene at 50 °C [5c], When the sequence described in Scheme 12.4is applied to 5-hexynoic acid ethyl or methyl ester (3c,d), no transmetallation-1,4-addition reaction was observed. These failures to transmetallate may be a consequence of intra- and/or in-termolecular chelation of the ester carbonyl group with the Zr(IV) present (Scheme 12.5) [5]. 

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See also in sourсe #XX -- [ , ]

See also in sourсe #XX -- [ , ]

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