Heterotopic heart transplantation

Heterotopic heart transplantation (h-HTX) was clinically established by Barnard and Losman (1977), who first implanted an auxiliary heart. The... 

Cooper DKC, Taniguchi S (1996) Heterotopic heart transplantation - indications, surgical techniques and special considerations. In Cooper DKC, Miller LW, Patterson GA (eds) The transplantation and replacement of thoracic organs. Kluwer, Dordrecht, pp 353-365... 

Hausen B, Boeke K, Berry GJ et al. Viral serine proteinase inhibitor (serp-1) effectively decreases the incidence of graft vasculopathy in heterotopic heart allografts. Transplantation 2001 72 364-368... 

Cardiac transplantation is the ultimate therapeutic option in end-stage CHF. Orthotopic cardiac transplantation is the surgical technique of choice, whereas heterotopic cardiac transplantation is performed primarily when there is high resistance in the pulmonary circulation of the recipient (and a heart-lung transplantation is impossible), the donor heart is too small, or in selected cases with acute but potentially reversible heart failure. In orthotopic transplantation the donor heart is joined to the recipients atria, aorta, and pulmonary artery. In heterotopic transplantation, the donor heart is implanted into the right thoracic cavity and anastomosed with the recipient s heart in a complex maimer in such a way that the donor heart takes over most of left ventricular output, while the recipient s heart continues to ensure right ventricular output. 

Antretter H, Poelzl G, Margreiter J et al (2002b) Successful transfer of a cardiac allograft from a heterotopic to an orthotopic position 16 years after heart transplantation. Transplantation 74 540-543... 

Huang XH, Reichenspumer H, Shorthouse R, Cao W, Berry G, Morris R. Heterotopic tracheal allograft transplantation a new model to study the molecular events causing obliterative airway disease in rats. J Heart Lung Transplant 1995 14 849. 

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