Heterocyclic compounds Dieckmann reaction

Many of the standard methods of C-C bond formation in aliphatic systems can be extended to heterocyclic systems, e.g. the Dieckmann reaction (,cf 51 — 52) and alkylation of active methylene compounds (e.g. 53 —+ 54). 

Many of the standard methods of C-C bond formation in aliphatic systems can be extended to heterocyclic systems, e.g., the Dieckmann reaction (cf. 66 67) and alkylation of active methylene compounds (e.g., 68 69). An example of the application of the Dieckmann reaction to the preparation of 3-thiepanone 70 is shown in Scheme 42 <1952JA917>. Several more recent examples of applications of the Dieckmann condensation in the synthesis of substituted 4- and 3-piperidones are discussed in CHEC-III . 

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