Heterocycles, acylation metal carbenes

Generally, isocyanides can be attacked by proton bases HX (X = OR, RNH) in a nucleophilic reaction that leads to acylic heterocarbene complexes [27, 28] The use of functionalized isocyanides containing both the isocyanide group and the nucleophile in the same molecule gives access to complexes with heterocyclic carbene ligands via an 1,2-addition across the C=N triple bond [29]. A number of research groups have been active in the development of nucleophile-functionalized isocyanides, which could subsequently be cyclized in metal template-controlled reactions. 

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