Hetero-oligomer synthesis

Gibbons, W. A., Hughes, R. A., Charalambous, M., et al. (1990) Synthesis, resolution and structural elucidation of lipidic amino acids and their homo- and hetero-oligomers. Liebigs Ann. Chem. 12, 1175-1183. 

Calix[n]arenes are cyclic condensation products of para-substituted phenol derivatives and formaldehyde [29], They are highly interesting for the development of sensitive coatings due to their conformational flexibility and the ease by which they may be modified chemically. Chemical modification can be done either in the meta position, or by reactions at the hydroxy group. In this way, bulky substituents [30], chelating substituents [31], aromatic residues [32], crown ethers [33,34], peptides [35,36], etc. can be introduced. A first approach to combinatorial synthesis of calix[4]arene receptors has been published by Reinhoudt and co-workers [37,38], who prepared calixarenes with different substituents. In solution, these calixarenes lead to formation of hetero-oligomers with barbiturates, and these hetero-oligomers were detected by MALDI-TOF mass spectrometry and H-NMR spectroscopy. 

Heterocyclic iminium salts, oxidative transformation, 41, 275 Heterocyclic mesomeric betaines and analogs in natural product chemistry, 85, 67 Heterocyclic oligomers, 15, 1 Heterocyclic products, natural, synthesis of by hetero Diels-Alder cycloaddition reactions, 42, 245... 

---