Hetero COSY spectra

The hetero-COSY spectrum of vasicinone along with the H-NMR assignments and C-NMR data are shown. Assign the C-NMR chemical shifts to the various protonated carbons based on the one-bond hetero-nuclear shift correlations. 

FIGURE 24.5 Comparison of H- F correlation 2D-NMR experiments of C2F5(VDF>2l in acetone-dg at 25°C H- F HMQC NMR spectrum and (b) hetero-COSY NMR... 

In our definition, real 2D NMR data are either homo- or hetero-nuclear data, where Fourier transformation is performed in both directions and a chemical shift map is created, as seen in COSY, TOCSY, NOESY, J-RES, HSQC, etc. In the case of HSQC, a short delay is being incremented during which the signals in the ID spectrum are being coded with the frequency of the corresponding hetero-nucleus and 2D Fourier transformation is employed to create the frequency map. An example of a real 2D NMR spectrum can be seen in Fig. 3A. With homo-nuclear data a similar picture is obtained, but the plot is symmetrical on the diagonal axis. 

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