Hesse, Bernhard

As this would require time, Wiley arranged for color policy to be deferred from the initial regulations that were to be issued before the act became effective on January 1. When the Department of Agriculture issued the regulations in October, it noted simply that "the Secretary of Agriculture shall determine from time to time. . . the principles which shall guide the use of colors" (4). Neither Wiley nor any of his staff was familiar with these dyes, so in mid summer he hired an outside consultant, Dr. Bernhard C. Hesse of New York City, to study the question. Hesse agreed to devote twenty hours a week to this project (5). 

B-75MI30800 M. Hesse and H. O. Bernhard Alkaloide , (Progress in Mass Spectrometry,... 

The Pure Food and Drug Act of 1906 listed seven colors, based on the work of Dr. Bernhard Hesse, and the Department of Agriculture made provisions for certification of all food colors on a voluntary basis. 

An important aspect of MS (especially electron impact) is fragmentation, which is characteristic for each compound. With methods like FAB and FD, this characteristic feature is often lost. Fragmentation patterns do give useful information about the structure of a compound. Loss of certain groups, or specific fragments for a certain class of compounds, are important information for the structure elucidation. Furthermore, with high resolution mass spectrometry, the elemental composition of the molecule can be obtained. The MS of alkaloids has been extensively reviewed by Hesse (1974) and Hesse and Bernhard (1975). 

Hesse M, Bernhard HO (1975) Progress in mass spectrometry, vol 3. Mass spectrometry of alkaloids. Verlag Chemie, Weinheim... 

Hesse M and Bernhard HO (1975) Progress in Mass Spectrometry, vol. 3, Mass Spectrometry of Alkaloids. Weinheim Verlag Chemie. 

William H. Nichols, Address, JIEC 9 (October 1917) 924 Bernhard C. Hesse, Contributions of the Chemists to... 

Bernard Conrad Hesse, 1869-1934, The Percolator (Chemists Club), April 21, 1934 Interview with Dr. Hesse, 1899 Bernard Conrad Hesse, 89p, 93, August 1934, all clippings in the necrology file of Bernhard C. Hesse, University of Michigan alumni collection, Bentley Historical... 

Wheeler testimony, July 26, 1882, excerpted in Bernhard C. Hesse, Lest We Forget Who Killed Cock Robin The U.S. Tariff History of Coal Tar Dyes, J/ C 7 (August 1915) ... 

The remarkable stability of acyl enzymes also indicates that protein conformation is stabilized in several steps in the catalytic process (Bender and Kezdy, 1964 Zerner and Bender 1964 Bernhard and Lau, 1972 Bernhard and Rossi, 1968). Acyl proteases are locked in a conformation which prevents acid and alkaline transitions, (Hess et al., 1970, GhHis, 1971). Stabilization of the acyl enzyme (DIP or tosyl elastase) is indicated by a shift of the transition curve, transition being induced by GuHCl, toward higher concentrations of denaturant (c , varies from 1.6 for elastase to 2.3 for DIP elastase at pH 5.4 and from 2.6 to 3.25 for these two forms respectively at pH 8.0) (Gh61is and Zilber, 1982). 

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