Herveline

Herveline A (66) H. voyronii Entire plant Stem bark [39] [11,12]... 

Herveline A (66) is a pavine-benzyltetrahydroisoquinoline dimer, and its molecular formula was determined as C39H44O7N2 by HREIMS (obsd m/z 652.3140) [11]. The UV absorptions at 282 and 319 nm were indicative of a bisbenzylisoquinoline skeleton [37], The H-NMR spectrum of 66 revealed the presence of two JV-methyl groups, five methoxy groups, one A2B2 system, and five aromatic singlet protons [11]. In addition, three CH-CH2 and one CH2-CH2 units were identified by H-... 

H homonuclear correlation spectroscopy (COSY). The connection between the benzyltetraisoquinoline and pavine moieties in 66 was located at C-10 and C-7 through an ether bridge as a result of the unambiguous assignments of H and 13C NMR signals by the heteronuclear multiple-bond quantum coherence (HMQC) and heteronuclear multiple-bond coherence (HMBC) NMR techniques. The EIMS of 66 confirmed the presence of a hydroxybenzyl moiety due to the observed complementary peaks at m/z 545 and 107 [11]. Furthermore, the structure of 66 was substantiated by the formation of herveline C (68) after 66 was treated with diazomethane in ethyl ether solution overnight [11]. 

Herbacin hydroxybutenolidc, H-20040 Herbamidc A. H-30040 Herbipoline. H-20041 Herculin. in D-10301 Hericcnone F, H-10033 Hericenone G. H-I0034 Hericenone H. H-10035 Herveline A, in H-30041 Hcrveline B. in H-30041 Herveline C, H-30041... 

Herveline A VIII VIII. 1 H. voyronii Jum. (syn. Hazomalania Entire plant Madagascar 48 ... 

Herveline B VIII VIII.2 H. voyronii Jum. Stem bark Madagascar 8,9 ... 

Herveline HB VIII VIII.5 H. voyronii Jum. Entire plant Madagascar 48 H... 

Antimalarial - in vitro Plasmodium falciparum), cone, used not stated. Reverses chloroquine resistance 8 P. falciparum, IC50 2.81 pM) vs. chloroquine-resistant strain FCM-29/Cameroon, and at 1.50 pM. Compound decreased IC50 value of Herveline D. A mixture of pure compounds was used to obtain the reported effect. 

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