Hernandia reticuline from

Thalicarpine was isolated from Cocculus laurifolius (73) in 1982. It is one of the rare examples of a tetrahydrobenzylisoquinoline-aporphine dimer. Thalicarpine seems to originate biogenetically from the oxidative coupling of two molecules of reticuline forming initially a Bis-BIQ. A second oxidative coupling, this one intramolecular, leads to the final product (Scheme 22). This alkaloid was also isolated from Thalictrum spp. (Ranunculaceae) and Hernandia ovigera (Hemandiaceae). 

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