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HERG repolarization assays

Martin, R.L., McDermott, J.S., Salmen, H.J., Palmatier, J., Cox, B.F., and Gintant, G.A., The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization influence of multi-channel block, /. Cardiovasc. Pharmacol, 43, 369-379, 2004. [Pg.282]

While APD/repolarization assays are suggested as one approach to explore the risk for delayed repolarization (ICH S7B guidance), they are generally not widely used at present, likely due to the ease of use (and interpretation) of hERG current assays conpared to AP/repolarization studies in supporting regulatory submission, lack of accepted industry best-standard/practices for APD/repolarization assays, as well as potentially important differences in ventricular repolarization across species (vs. humans). For exanple, it is well established that I,j/hERG plays a prominent role in... [Pg.135]

See other pages where HERG repolarization assays is mentioned: [Pg.270]    [Pg.403]    [Pg.36]    [Pg.42]    [Pg.46]    [Pg.136]    [Pg.140]    [Pg.161]    [Pg.127]    [Pg.58]    [Pg.318]    [Pg.40]    [Pg.41]    [Pg.49]    [Pg.4]    [Pg.7]    [Pg.131]    [Pg.134]    [Pg.137]    [Pg.141]    [Pg.185]    [Pg.63]    [Pg.394]   
See also in sourсe #XX -- [ Pg.42 ]



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