HERG potassium channel inhibitors

Tobita, M., Nishikawa, T. and Nagashima, R. (2005) A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic el Medicinal Chemistry Letters, 15, 2886-2890. 

A Discriminant Model Constructed by the Support Vector Machine Method for HERG Potassium Channel Inhibitors. 

For example, studies on liver cytochrome P450 enzymes would be performed to determine whether the drug of interest is likely to be a substrate or inhibitor of these enzymes or to interfere with the metabolism of other drugs. Effects on cardiac ion channels such as the hERG potassium channel, possibly predictive of life-threatening arrhythmias, are considered. 

Xia MH, Shahane SA, Huang RL et al (2011) Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels. Toxicol Appl Pharmacol 252(3) 250-258... 

Thomas D, Gut B, Wendt-Nordahl G, Kiehn J (2002) The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels. J Pharmacol Exp Ther 300 543-548... 

Melgari D, Brack KE, Zhang C et al (2015) hERG potassium chaimel blockade by the HCN channel inhibitor bradycatdic agent ivabradine. J Am Heart Assoc 4 pii e001813... 

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