HERG inactivated state

Walker BD, Singleton CB, Bursill JA, et al. Inhibition of the human ether-a-go-go-related gene (HERG) potassium channel by cisapride Affinity for open and inactivated states. Br J Pharmacol 1999 128 444 50. 

Chen, J., Seebohm, G. and Sanguinetti, M.C. (2002) Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of hERG and eag potassium channels. Proceedings of the National Academy of Sciences of the United States of America, 99, 12461-12466. 

Figure 1 (a) The transmembrane topology of a hERG potassium channel subunit is depicted, (b) hERG potassium channel state is dependent on membrane potential. Depolarization favors the open (O) and inactivated (I) states, while hyperpolarization induces channel closing (C). 

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