Hepatotoxicity clozapine

Hummer M, Kurz M, Kurzthaler I, Oberbauer H, Miller C, Fleischhacker WW. Hepatotoxicity of clozapine. J Clin Psychopharmacol 1997 17(4) 314-7. 

Macfarlane B, Davies S, Mannan K, Sarsam R, Pariente D, Dooley J. Fatal acute fulminant liver failure due to clozapine a case report and review of clozapine-induced hepatotoxicity. Gastroenterology 1997 112(5) 1707-9. 

Hepatitis occurred in a 43-year-old woman taking risperidone 6 mg/day and clozapine 600 mg/day [135 ]. The condition completely remitted after switching to paliperidone. Although clozapine itself or the combination of the two drugs could not be ruled out as the cause of the hepatitis, treatment with clozapine was almost unchanged, and the authors attributed the hepatotoxic-ity to risperidone. 

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