Hepatic portal vein concentration

Water-soluble products of digestion are transported directly to the fiver via the hepatic portal vein. The fiver regulates die blood concentrations of glucose and amino acids. 

The hepatic artery supplies the liver with 300 ml/min of oxygenated blood from the aorta. The remaining 1050 ml/min of blood flow is delivered by the hepatic portal vein. This blood comes directly from the digestive tract. It is low in oxygen but contains a high concentration of nutrients absorbed from the intestines. 

Concentration of compound in rat plasma obtained from hepatic portal vein (hpv). 

The ammonia produced from asparagine and glutamine is released into the hepatic portal vein, for removal by the liver and conversion to urea. The concentration of ammonia in the blood in the hepatic portal vein is about ten times higher than in the hepatic vein, indicating the quantitative importance of the liver in removing this ammonia. 

When a drug is administered orally, the plasma drug concentration depends on the distribution pathways. For example, if the drug is present in high concentration in the hepatic portal vein, the occurrence of the first-pass effect decreases the amount of drug that reaches the circulation. 

FIG. 1 Movement of cholesterol (CHOL) and bile acids (BA) between the liver and small intestine. CHOL and BA in the liver are secreted into the gallbladder where they are stored temporarily until a fat-containing meal causes their secretion into the intestinal lumen. BA are absorbed with high efficiency (95%) and are recycled back to the liver via the hepatic portal vein. CHOL is absorbed less efficiently (50-60%) and must be incorporated into lipoproteins (chylomicrons) for transport back to the fiver via the systemic circulation. Accumulation of CHOL in the liver can promote secretion of CHOL into plasma, thus increasing LDL-CHOL concentration. Loss of CHOL and BA in feces represents the primary route of CHOL elimination from the body. 

Finally, Fg is derived experimentally from peripheral venous plasma concentrations after dosing to the hepatic portal vein and the superior mesenteric artery, respectively, according to Equation 12.4 ... 

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