Heparin-induced thrombocytopenia alternative anticoagulants

Manfredi JA, Wall RP Sane DC, et al. Lepirudin as a safe alternative for effective anticoagulation in patients with known heparin-induced thrombocytopenia undergoing percutaneous coronary intervention case reports. Catheter Cardiovasc Interv 2001 52 468 -72. 

Alternative anticoagulant for heparin-induced thrombocytopenia patients undergoing percutaneous coronary intervention... 

T ble 6 Alternative anticoagulants in percutaneous coronary intervention in heparin-induced thrombocytopenia... 

UFH can cause autoimmune heparin-induced thrombocytopenia. This rare but potentially lethal complication is associated with thrombosis and is treated by prompt withdrawal of UFH and initiation of alternative anticoagulation therapy. 

Hematologic Numerous papers on heparin-induced thrombocytopenia continue to appear, including a systematic review of the use of argatroban as an alternative anticoagulant [16 ]. Two prospective, multicenter, non-randomized, open studies of the use of argatroban... 

Although many reports have shown that alternative anticoagulants do not also cause thrombocytopenia in patients with heparin-induced thrombocytopenia, occasional exceptions are reported, as in the cases of thrombocytopenia due to fonda-parinux (qv below). 

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