Heparin deamination degradation

In addition to neutrophils, endothelial cells were also used to degrade a variety of important GAGs. Although these cells were able to degrade heparin, that is very sensitive to a NO-dependent deaminative cleavage, HA is not susceptible to this pathway and thus, it can be concluded that endothelial cells are not capable of generating ROS that lead to the degradation of HA [91]. 

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