Heparin carboxylic derivatives, anticoagulant

Table I. Carboxylic Derivatives (Heparin-C-N-R) and Their Anticoagulant Activities...

Finally, the hetero polysaccharide hexagluconylhexasaminoglycan sulfate was identified as an anticoagulant and antithrombotic material compared to heparin by Sederel and coworkers [521], Derivatives of the polysaccharide dextran containing sulfate, sulfonate or carboxylic groups gave antithrombotic activity due to the presence of these charged groups [483, 522-525],... 

It is known that sulfated polysaccharides, including natural and synthesized ones, had great blood-compatibility or even anticoagulant activity [34]. After sulfation of sodium alginate, its derivative contains both sulfate and carboxyl groups, whose chemical structure is analogous to the natural blood anticoagulant heparin. Fan et al. 

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