Heparin aspirin and

When the classic anticoagulants are described in some recent publications, they are often labeled as bad drugs with many adverse effects. In fact, the classical anticoagulants may not have any more adverse effects than the newer drugs. Needless to say, all pharmacologic agents have their limitations. Heparin, aspirin, and warfarin certainly have drawbacks, some of which have already been addressed, although improvements have been made. 

Modi NB, Lin YS, Reynolds T, Shaheen A, Christian BC. Pharmacokinetics of Xubix, an orally active Ilbllla antagonist, in the presence of heparin, aspirin and rt-PA in beagles. J Cardiovas Pharmacol 1998 32 397 105. 

A 62-year-old hypertensive man with renal artery stenosis, an adrenal adenoma, peripheral artery disease, and an abdominal aortic aneurysm developed a hypertensive crisis with chest pain. He was treated with nitrates, heparin, aspirin, and nicardipine, which were afterwards replaced by diltiazem 200 mg/day, because of persistent chest pain. He developed atrioventricular block 2 hours after the second dose of diltiazem, and was successfully treated with a pacemaker. 

Modi, N. B. et al., Pharmacokinetics and pharmacodynamics of sibrafiban (Ro 48-3657), an orally active Ilbllla antagonist, administered alone or in combination with heparin, aspirin and recombinant tissue-type plasminogen activator in beagles, J. Cardiovasc. Pharmacol., 32 397M05, 1998. 

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