Heparin administration, optimization

The purpose of this paper is to illustrate how mathematical modeling and control theory can be applied to the problem of optimizing the administration of the anticoagulant drug heparin. 

Promoting an Optimal Response to Therapy Heparin preparations, unlike warfarin, must be given by the parenteral route preferably SC or IV The onset of anticoagiilation is almost immediate after a single dose. Maximum effects occur widiiii 10 minutes of administration. Clotting time will return to iionnal widiiii 4 hours unless subsequent doses are given. 

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