Heparanase cleavage of heparin

In contrast to L-iduronic acid residues, most of which are sulfated at C-2, D-glucuronic acid residues in heparin and heparan sulfate are largely or exclusively nonsulfated. This was especially proved by their susceptibility to periodate oxidation, and through characterization of D-glucuronic acid-containing di- and tetra-saccharides from deamina-tive or heparinase - heparanase cleavage - of heparin. 

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