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Hemolytic drug reaction

Van Arsdel PP Jr (1978) Adverse drug reactions. In Middleton E Jr, Reed CE, Ellis EF (eds) Allergy principles and practice, vol 2. Mosby, St. Louis, p 1133 Van Arsdel PP Jr, Franz KB (1963) Nature of antibody in penicillin-induced hemolytic anemia. J Clin Invest 42 988... [Pg.132]

Examples of type II cytotoxic antibody-mediated drug reactions include drug-induced immune hemolytic anemia, drug-induced thrombocytopenia where a number of different mechanisms are involved and acute agranulocytosis in which more than 70 % of cases are caused by drugs... [Pg.89]

Acetaminophen causes few adverse reactions when used as directed on the label or recommended by the primary health care provider. Adverse reactions associated with the use of acetaminophen usually occur with chronic use or when the recommended dosage is exceeded. Adverse reactions to acetaminophen include skin eruptions, urticaria (hives), hemolytic anemia, pancytopenia (a reduction in all cellular components of the blood), hypoglycemia, jaundice (yellow discoloration of the skin), hepatotoxicily (damage to the liver), and hepatic failure (seen in chronic alcoholics taking the drug). [Pg.153]

Type II reactions are produced by IgG (or IgM) antibody. The drug or hapten that elicited the antibody response binds to target cells. When antibody binds the drug, complement activation destroys the cell. Blood dyscrasias such as thrombocytopenia and hemolytic anemia are the most common examples of type II reactions. [Pg.821]

The answer is a. (Katzung, p 162.) Many drugs can cause an immunohemolytic anemia. Methyldopa may cause a positive Coombs test in as many as 20% of patients, along with hemolytic anemia. Other drugs with similar actions on red blood cells are penicillins, quinidine, procainamide, and sulfonamides. These form a stable or unstable hapten on the red cell surface, which induces an immune reaction I immunoglobulin G (IgG) antibodies] and leads to dissolution of the membrane. [Pg.122]

II cytolytic Cell-associated Clonal expansion B cells IgM, IgG generated. Ig binds to cell bound antigen in the presence of complement and/or activated macrophages cell lysis occurs Rh factor incompatability, hemolytic anemeia in reaction to drugs... [Pg.546]

Urinary aikaiinization In the treatment of certain drug intoxications (eg, salicylates, lithium) and in hemolytic reactions requiring aikaiinization of the urine to diminish nephrotoxicity of blood pigments. [Pg.39]

NSAIDs. Hematopoietic side effects (e.g., leukopenia, hemolytic anemia, aplastic anemia, purpura, thrombocytopenia, and agranulocytosis) also may occur. Ocular effects (blurred vision, corneal deposits) have been observed in patients receiving indomethacin, and regular ophthalmological examinations are necessary when the drug is used for long periods. Hepatitis, jaundice, pancreatitis, and hypersensitivity reactions also have been noted. [Pg.430]

Mild to moderate side effects, including nausea, vomiting, abdominal pain, diarrhea, anorexia, and headache, occur in up to 33% of patients taking this drug. Skin rash and discoloration, fever, reversible male infertility, and liver enzyme elevation occur less frequently. Rare hematological abnormalities, such as agranulocytosis, aplastic anemia, hemolytic anemia, neutropenia, or other blood dyscrasias, can be fatal. Hypersensitivity reactions occur rarely. [Pg.433]

Allergic reactions (e.g., rashes, urticaria, and eosino-philia) have been observed. These drugs have occasionally been associated with cholestatic jaundice, blood dyscrasias, hemolytic anemia, hypoglycemia, and nephrotoxicity. Recently the use of ciprofloxacin for prophylaxis protection against anthrax infection has been associated with damage to muscle ligaments. [Pg.521]

Overdose may lead to hemolytic anemia, nephrotoxicity, or hepatotoxicity. Patients with renal impairment or severe hypersensitivity to the drug may also develop these reactions. [Pg.968]

Cephalosporins are sensitizing and may elicit a variety of hypersensitivity reactions that are identical to those of penicillins, including anaphylaxis, fever, skin rashes, nephritis, granulocytopenia, and hemolytic anemia. However, the chemical nucleus of cephalosporins is sufficiently different from that of penicillins so that some individuals with a history of penicillin allergy may tolerate cephalosporins. The frequency of cross-allergenicity between the two groups of drugs is uncertain but is probably around 5-10%. However, patients with a history of anaphylaxis to penicillins should not receive cephalosporins. [Pg.993]

Dapsone (Avlosulfon) is a member of a class of chemical agents known as the sulfones. Dapsone is especially effective against M. leprae and is used with rifampin as the primary method of treating leprosy. Dapsone appears to exert its antibacterial effects in a manner similar to that of the sulfonamide drugs that is, dapsone impairs folic acid synthesis by competing with PABA in bacterial cells. Primary adverse effects associated with dapsone include peripheral motor weakness, hypersensitivity reactions (skin rashes, itching), fever, and blood dyscrasias, such as hemolytic anemia. [Pg.511]

The problems encountered most frequently with sulfonamide drugs include gastrointestinal distress, increased skin sensitivity to ultraviolet light, and allergic reactions. Serious disturbances in the formed blood elements, including blood dyscrasias such as agranulocytosis and hemolytic anemia, may also occur during systemic sulfonamide therapy. [Pg.512]


See other pages where Hemolytic drug reaction is mentioned: [Pg.820]    [Pg.7]    [Pg.455]    [Pg.363]    [Pg.3444]    [Pg.1604]    [Pg.1875]    [Pg.7]    [Pg.84]    [Pg.154]    [Pg.380]    [Pg.241]    [Pg.247]    [Pg.117]    [Pg.226]    [Pg.278]    [Pg.293]    [Pg.272]    [Pg.553]    [Pg.10]    [Pg.987]    [Pg.1703]    [Pg.1913]    [Pg.517]    [Pg.989]    [Pg.1187]    [Pg.149]    [Pg.378]    [Pg.399]    [Pg.152]    [Pg.1565]    [Pg.129]    [Pg.32]   
See also in sourсe #XX -- [ Pg.1604 ]




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