Hemoglobin folding pattern

Figure 7-23 Folding pattern of the hemoglobin monomers. The pattern shown is for the P chain of human hemoglobin. Some of the differences between this and the a chain and myoglobin are indicated. Evolutionarily conserved residues are indicated by boxes, I I highly conserved, I I invariant. Other markings show substitutions observed in some abnormal human hemoglobins. Conserved residues are numbered according to their location in one of the helices A-H, while mutant hemoglobins are indicated by the position of the substitution in the entire a and P chain.

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